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Rating: 4.3969000000000005 (22 reviews)

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Description

Vergani, L

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Rodents infused with angiotensin II had greater gut permeability as assessed by FITC-Dextran [92, 48] and decreased intestinal gene expression of tight junction proteins including ZO-1, particularly on a low fibre diet [48, 96], which was accompanied by increased intestinal expression of the inflammatory cytokines TNF- and IL-6 [96]

Oxidative stress and mitochondrial reactive oxygen species The mitochondrial ETC is the major source of intracellular ROS production [72], and mitochondrial dysfunction can lead to increased levels of superoxides, hydrogen peroxide, and hydroxyl radicals [73]