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Key reversible modifications include the following: i) S-glutathionylation (SSG), where GSH adduct formation occurs via thiol-disulfide exchange

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1.2.1 High resolution structural technology High-resolution structural techniques are primarily employed in the early stages of drug discovery, where the resolution of drug-target complex structures helps address the critical question of "how drugs bind to their targets." The high-resolution crystal structure of monkeypox virus I7L protease provides both structural insights and a lead compound for developing broad-spectrum antiviral drugs targeting orthopoxviruses