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Cancer treatment increasingly employs combination approaches that may include peptide-based targeted therapies alongside traditional chemotherapy, radiation, or immunotherapy

4 Current challenges and prospects 4.1 Therapeutic targeting potential of TGF- 4.1.1 TGF- downstream effectors The therapeutic targeting of TGF- and its downstream effectors, particularly the Smad proteins, presents a promising avenue in fibrosis treatment

Although this may offer systemic recovery and healing benefits, it introduces complexity in predicting responsesespecially in polypharmacy and comorbidity contexts

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