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Conversely, Habif et al

It permits non-enzymatic and enzymatic antioxidative ROS detoxification

ADP-ribose interacts with the Mac1 hydrophobic cleft through conserved hydrogen bonds 68

Although the highest PUFA content is found in adipose tissue, PUFA in brain tissue accounts for 30%35% of the total fatty acid content, so the central nervous system is very vulnerable to lipid peroxidation (Peng et al., 2021)

Compared with traditional therapy modalities, nanoparticles improve the targeting efficiency of mitochondria, enhance the stability and bioavailability of therapeutics, and reduce the side effects on other non-target sites