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This is not surprising as only 23% of children with ASD and MD have a known mtDNA abnormality

CoQ10 supplementation, when added to pregabalin, significantly reduced pain and mitochondrial oxidative stress in FM patients, with improved anxiety and brain activity profiles in a small RCT ( Oxygen-ozone (OO) therapy, an intervention that activates NRF2, increases SOD, catalase, and HO-1, while suppressing pro-inflammatory cytokines (IL-6, TNF-, IL-1) ( , HO), protecting mitochondria, and enhancing ATP production ( Molecular hydrogen (H) is emerging as a potential therapy targeting oxidative stress, mitochondrial dysfunction, and inflammation

Hazen, who also holds the Jan Bleeksma Chair in Vascular Cell Biology and Atherosclerosis, has previously linked TMAO to an increased risk of cardiovascular disease and has shown it can be a powerful tool for predicting future heart attacks, stroke and death in multiple patient populations

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