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VSMC proliferation and intimal thickening also predispose individuals to oscillatory or low blood flow, which have been shown to induce leukocyte adhesion, enhanced vascular permeability, LDL oxidation, and atherosclerotic plaque formation 42,43,44

Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment

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doi: 10.1016/j.pharmthera.2007.09.008, 109

4m) self-assembled from a PROTAC, a singlet oxygen-cleavable linker, and an NIR photosensitiser