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Pigment lightening develops gradually

In other studies, OA and its derivatives downregulated the Akt/mTOR/S6K and ERK1/2 pathways [282], influenced the miR-122/Cyclin G1/MEF2P pathway by overexpression of tumor suppressive miR-122 [284], or altered the expression of glycolytic enzymes [285]

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The CFTR protein resides on the apical surface of epithelial cells and functions as a cyclic adenosine monophosphate (AMP)-dependent ion channel, modulating the flux of ions into and out of the cell

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