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Depleted levels of glutathione are recognized to result in susceptibility to cellular deterioration, as a result of multiple circumstances, including oxidative stress, free radical exposure, infections, and toxins.*

However, inhibiting these enzymes with specific inhibitors leads to inhibition in pollen tube growth due to low or non-accumulation of ROS [76]

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Harris BE, Song R, Soong SJ, Diasio RB (1990) Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion

Menkes syndrome and animal models