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PMID: 306 AhnJSShinSYangSAParkEKKimKHChoSIet al

Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling

The sensitivity of the forward rate constants for the superoxide formation reaction, k p2 , and the oxygen concentration parameter, k O2 , proved to be the most sensitive globally with respect to total effects, highlighted in Fig