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Neutrophils and macrophages also release reactive oxygen species, pro-inflammatory cytokines, growth factors and MMPs, which propagate chronic inflammation, emphysema, and airway remodelling processes, such as EMT, fibroblast activation and airway smooth muscle proliferation ( Figure 3 )

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(Rite Aid, at least, has since reconsidered.) It will now be interesting to see if CVS does the same