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doi: 10.1016/j.tcm.2019.05.001 13 CarioE

Studies suggest that regional anesthesia, such as paravertebral and epidural blocks may preserve NK cell function, improve Th1/Th2 balance and reduce the need for opioids

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Durr a, Adams D, Corvol J-C, Mariani L-L

However, the clinical use of natural agonists is limited by poor bioavailability, while synthetic agents like thiazolidinediones are associated with adverse effects, including fluid retention, weight gain, and bone loss