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Professor Giovanna Traina from the University of Perugia explained via email to GMFH editors that a healthy intestinal barrier is essential for the maintenance of gastrointestinal health, but also for the systemic health of the host, as it is able to preserve the potential translocation of bacteria, food allergens, xenobiotics and inflammatory mediators in the systemic circulation, that may compromise the functionality of other organs. Such a defect in the gut barrier may facilitate dietary and microbial antigen influx, leading to the chronic inflammation involved in the onset of modern diseases

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2020;34 Suppl 3:1218

Beyond heart rate concerns, the combination creates a cascade of overlapping side effects: nausea from semaglutide paired with appetite suppression from phentermine can lead to inadequate calorie and nutrient intake

Existing studies are generally small in sample size and limited in follow-up duration