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One study reported no change in mean lifespan, although maximum-lifespan and longest-survivor measurements differed

Sergey Terushkin, MD, FACS Key Takeaways Turn on the news or scroll through TikTok, and you will see it: Semaglutide (Ozempic, Wegovy) and Tirzepatide (Mounjaro, Zepbound) are being hailed as the end of obesity. And in many ways, they are

Practical supports that improve long-term results Progressive loading: structured strengthening that increases capacity gradually Movement quality: correcting compensation patterns that overload tissue Adequate protein: collagen remodeling requires amino acids Sleep optimization: recovery signaling deteriorates when sleep is poor Metabolic support: insulin resistance and systemic inflammation impair healing When these elements align, the tissue receives both the biochemical support and the mechanical signal required for durable remodeling

J Biol Chem (2013) 288(28):2074557

However, a key counterargument challenges a direct causative role