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284 A similar phenomenon has been observed in Gln-dependent clear cell renal carcinoma (RCC), which competitively depletes environmental Gln, causing local Gln depletion and IL-23 release from tumor-infiltrating macrophages, which further activates Treg function to suppress tumor immunity

[PubMed: 12700031] 163

357 Modern CFE systems enable the manufacture of full-length heterotetrametric IgG antibodies with yields from 114 g/mL (Chinese hamster ovary cell (CHO) CFE, glycosylated) 107 to 150 g/mL ( N