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As I wrote in Canada's leading medical journal in November 2008, "the fact that cessation with pharmacological treatment has failed to be more successful than cessation without such treatment in nearly all of real-world surveys conducted to date, strongly suggests that the pharmacologic treatment of chemical dependency may be the only known research area in which blinding is impossible." The FDA must by now be fully aware that drug addiction may be the only pharmacology study area where blinding actually punishes participants, in making them vastly worse than when they arrived, by throwing them into full-blown drug withdrawal

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Simmons, MD New York State Journal of Medicine , vol