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And that Harvard chemist on the surgeon general's panel who smoked four packs a day was diagnosed with lung cancer within a year of the 1964 report, and died of the disease

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Indeed, it was identified that phosphorylation of VDAC1 is necessary in Parkin-mediated mitophagy, during which the adapter protein p62 exerts a pivotal role in the clearance of damaged mitochondria since Parkin-dependent mitophagy requires p62/SQSTM1/sequestosome-1 recruitment to the clustered mitochondria for final clearance