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However, if their concentrations within the blood should increase greatly because of excessive exposure to harmful factors such as smoking, then they cannot be regulated and may cause dangerous mutations that destroy cells

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Tobacco smoking is a major cause of lung cancer and chronic bronchitis.

I would say, that may be true for certain usersfor example, long time smokers that cannot quitbut the problem is, it doesnt mean that theyre healthy

Cotinine, the primary nicotine breakdown product, is commonly tested for in nicotine screening tests, along with other related substances, because it remains in the body longer than nicotine itself