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The result of that stress, isolation, and boredom is still being researched

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CVD are one of the most complex group of diseases, as they have a multifaceted pathomechanism and are subject to a variety of risk factors and genetic predispositions [15], which makes it hard to study chemical toxicity to the cardiovascular system mechanistically

Animal models have also demonstrated that PNE alters the development of the mesocorticolimbic system which is important for goal-directed behavior and its ability to modulate neural processes that contribute to drug abuse [166]