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Supplementary Material Acknowledgments Funding/Support: Research reported in this publication was supported by The National Cancer Institute and the FDA CTP under award No

Nicotine was once used as an insecticide, but it was abandoned due to its high toxicity, Dr

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increased mental health symptoms may lead to increased smoking as a coping strategy, and the onset of smoking may result in poorer physical health/quality of life, leading to symptoms of depression and anxiety)

In vitro , the main enzyme responsible for the glucuronidation of hydroxybupropion is UGT2B7, with a minor contribution from UGT2B4