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There were similar rates of mild adverse events (e.g., nausea, restlessness, insomnia, irritability) across groups in trials of cytisine based on our initial overview.22 However, an updated Cochrane review on cytisine42 suggested there may be a small increase in adverse events, which could constitute a small harm (4 RCTs, n = 4052

No tobacco could be imported except from Virginia, and a royal license that cost 15 pounds per year was required to sell it (equivalent to 3,300 in 2025)

To improve your REM sleep, you should avoid smoking cigarettes, especially a few hours before you sleep

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