Juan Nepomuceno Adorno of Mexico first patented a cigarette machine in 1847 although in the 1880s an additional machine was developed by James Albert Bonsack which increased the productivity of cigarette companies
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The European Journal of Public Health 2006

4.2.1 Drugs approved by FDA The targets that have drugs approved by FDA include EGFR (gefitinib (brand name: Iressa, company: ASTRAZENECA,London, the UK), erlotinib (brand name: Tarceva, company: OSI PHARMS, Ardsley, the USA), afatinib (brand name: Gilotrif, company: BOEHRINGER INGELHEIM, southwest Washington, the USA), dacomitinib (brand name: Vizimpro, company: PFIZER, New York City, the USA) and osimertinib (brand name: Tagrisso, company: ASTRAZENECA,London, the UK)), ALK (crizotinib (brand name: Xalkori, company: PF PRISM CV, Netherlands), alectinib (brand name: Alecensa, company: HOFFMANN-LA ROCHE, Basel, Switzerland), brigatinib (brand name: Alunbrig, company: TAKEDA PHARMS USA, Lexington, the USA), ceritinib (brand name: Zykadia, company: NOVARTIS, Basel, Switzerland), and lorlatinib (brand name: Lorbrena, location and company: PFIZER, New York City, the USA), ROS1 (crizotinib (brand name: Xalkori, company: PF PRISM CV, Netherlands), lorlatinib (brand name: Lorbrena, company: PFIZER, New York City, the USA), entrectinib (brand name: Rozlytrek, company: GENENTECH INC, Pennsylvania, the US) and brigatinib (brand name: Alunbrig, company: TAKEDA PHARMS USA, the USA), RET (pralsetinib (brand name: Gavreto, company: GENENTECH INC, Pennsylvania, the US) and selpercatinib (brand name: Retevmo, company: LOXO ONCOLOGY INC, Massachusetts, the USA)) (123, 125127)

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