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These factors themselves can affect CNS function and inflammatory status, making it difficult to isolate MG-specific CNS effects (169)

For example: The "Russian Protocol" described in some literature involves 10mg daily for 10 consecutive days The "Ukrainian Protocol" uses 10mg on days 1, 5, 9, 13, and 17 Both protocols suggest repeating cycles every 4-6 months These are research protocol descriptions, not recommendations for use

This increased bioavailability may be attributed to the orotate ion's ability to facilitate lithium transport across cell membranes