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To produce a biological effect, it is necessary to combine the cytokine with a specific receptor on target cells (T and B lymphocytes, natural killer cells, monocytes/macrophages, and granulocytes)

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It does not have the same level of clinical evidence as approved medications for inflammatory bowel disease, autoimmune disease, or other diagnosed inflammatory conditions

Most proteins and large peptides do not adopt completely uniform conformations, and full descriptions of their preferred three dimensional arrangements are defined as tertiary structures