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The telomere protects the DNA from damage each time the cell divides, but in the process of every cell division the telomere gets a bit shorter

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In both diseases the disturbed lipid metabolism in hepatocyte leads to intracellular build-up of potentially toxic bioactive lipid species causing endoplasmic reticulum (ER) stress, mitochondrial dysfunction and cellular death, which in turn triggers the innate immune response and activation of hepatic stellate cells (HSCs), resulting in inflammation and increased collagen production and deposition