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Here are a few things to consider before mixing marijuana and Lexapro (escitalopram): Some prescription medications can have adverse effects when mixed with alcohol or marijuana, including, potentially, some antidepressants Many people respond differently to the same type of drugs, so its not necessarily safe for everyone to smoke pot and take antidepressants just because another person didnt experience any side effects A lot of physicians will refuse to prescribe antidepressants if they know their patient is a pot user because there are few studies showing that mixing the two drugs is safe Over the long-term, chronic marijuana use can actually change the brains structure and function, causing a person to become more depressed Despite the idea in popular culture that weed is harmless, marijuana use disorder and addiction are very real and can create significant life problems and require treatment Can You Smoke Weed on Lexapro