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Unlike the nuclear genome, mitochondrial genomes lack histones, therefore, rather than histone-related modifications, research on mitochondrial gene expression regulation focused on mtDNA methylation and has demonstrated its differences in aging [35, 36] and various diseases including metabolic disorders [37, 38], neurodegeneration [39], and cardiovascular diseases [36, 40]

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64 Although the court acknowledged that the FTC has jurisdiction to define and enforce "unfair or deceptive acts or practices in or affecting commerce," it rejected the idea that "the degree of federal regulation over a particular industry, no matter how 'comprehensive' or 'detailed,' [could] itself displace state law." 65 If so, this would be "tantamount to saying that whenever a federal agency decides to step into a field, its regulation will be exclusive." 66 The court held that it had to determine whether the FTC's oversight of tar and nicotine claims manifests a federal policy intended to displace conflicting state law