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Description

JAMA Oncol 8(1):7987

BDNF phosphorylates Bad via Akt, preventing its binding to Bcl-xL, maintaining mitochondrial membrane potential stability and inhibiting Cyt C release [107]

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The novel findings generate new hypotheses regarding serine-folate-glycine one carbon and serine-phospholipid metabolism, elevation of end products of catabolic pathways, shifts in folate, thiamine and other vitamins with exercise, and changes in sphingomyelins that may indicate myelin and white matter dysfunction in ME/CFS