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This study will be relevant and of interest to NHS Trusts who are participating in this study where they will receive interim findings, those NHS Trusts who are not

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Ethics declarations Competing interests This study was funded by Imperial Brands PLC, the manufacturer of the Pulze Heated Tobacco System examined in this study

The risk to the environment is calculated as the sum of the risk of persistence, leaching to groundwater, aquatic organisms, birds, earthworms, and bees

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