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In this period, the trends in Australian alcohol and tobacco consumption per capita were divergent from the trend of liver cancer mortality rates

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In the subgroup analysis by intensity of use, there was no indication that higher intensity of snus use led to a worse lipid profile, given that men who consumed at least 4 cans per week had higher HDL cholesterol concentrations than those who consumed less than 4 cans per week ( p value = 0.02) (Supplementary Figure 3, upper panel)