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This pattern suggests that the major difference may lie more in gas exchange impairment than in airflow limitation

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Annotation and analysis of target genes via FUMA In our study, we utilized target genes obtained through the SMR method and further analyzed and annotated the results of genome-wide association studies (GWAS) using the FUMA platform ( By employing the GENE2FUNC tool and tissue-specific data provided by GTEx V8, we conducted in-depth annotations of these priority genes, aiming to explore their presumed biological mechanisms and expression patterns across various tissues