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Furthermore, the T2 cytokines IL-4 and IL-13 inhibit the expression of the key tight and adherens junction genes ZO-1, E-cadherin and occludin, and drive goblet cell differentiation from basal cells ( Figure 2 ) (13, 82)

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The findings were strongest among current smokers, a factor that could discourage quitting and might encourage switching to the brand, according to the researchers