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Compared with tobacco-only smokers, these patients were younger at diagnosis, more likely to report chest pain, had more emphysema and bullous changes, lower transfer capacity, and a greater proportion of rare and aggressive tumor types (Pradre et al., 2026)

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In addition to this indirect positive relationship between gene-body methylation and genome-wide gene expression, gene-body methylation may be involved in suppression of DNA transcription directly by, for example, inhibiting alternative promoters embedded in gene bodies (Maunakea et al., 2010), or by impeding RNA-polymerase transit and transcription elongation (Zilberman et al., 2007