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Link to the paper we discussed: Disclaimer: All opinions are our own

Octreotide (MW 1019 Da) offered the advantage of a relatively small increase in stability in intestinal fluid afforded by a macrocycle backbone, two D-amino acids, and a modified C terminus, 11 whereas semaglutide remained unstable in the GI tract despite being stable in plasma due to affinity of its fatty acid chains for albumin