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CHANGE-seq-BE paired-end reads should be in an outward orientation with some degree of self-overlapping bases

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As pack-years alone appear insufficient for modeling the effects of smoking, there have been calls to consider both duration and intensity in assessment of smoking exposure 12,13

"Since I've been in Delaware before and have good comedy connections here, we decided to do it in Delaware first." He says it's not as easy as one might think to get 15 comedians to smoke pot for work