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An in vivo study, using C57BL/6 mice exposed to 0.3 mg/kg dieldrin, showed differentially methylated CpG sites in regions related to dopaminergic differentiation

Unlike daily smokers who typically maintain consistent levels of nicotine exposure with regular smoking, non-daily smokers have variable patterns of smoking that likely result in high intraindividual variability in nicotine intake

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Gene Set Enrichment Analysis (GSEA) 104,105 was conducted to determine what gene sets were impacted by exposure to THC