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In future studies, it would be of considerable interest to understand how sustained smoking behaviour, driven initially by hedonic experience may further develop into dependence (i.e., psychological or physical craving for nicotine following withdraw), where habit-inducing regions such as the insula and striatum might eventually become involved 55,56

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Although the TCA expanded FDA's authority to regulate tobacco products in 2009, stakeholders have recently identified several issues related to the regulation of these products that may be of interest to Congress: These four issues are discussed in detail below, along with potential considerations for policymakers