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The nicotine in the inhaled e-cigarette aerosols may have negative effects on sleep architecture and disturb the neurotransmitters that regulate sleep cycle, they suggested, and since higher doses of nicotine produce greater reductions in sleep duration, those who use e-cigarette on a daily basis might consume higher doses of nicotine, compared to some days, former, and never users, and therefore get fewer hours of sleep. Nicotine withdrawal, on the other hand, has been found to increase sleep duration in a dose-dependent manner, which could explain the smaller [prevalence ratios] observed for the association between e-cigarette use and sleep deprivation among former and some days e-cigarette users, Dr