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"Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin"

When they switch to these products they rapidly reduce their consumption of cigarettes, they double their quit attempts and have more smoke free days, John Pritchard, 22nd Century Group regulatory science vice president, said

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They concluded that for women who smoke while pregnant "the risk was increased by 26% for having a baby with missing or deformed limbs, 28% for clubfoot, 27% for gastrointestinal defects, 33% for skull defects, 25% for eye defects and 28% for cleft lip/palate." The biggest increase in risk was for their baby having a birth defect called gastroschisis, in which part of its stomach or intestines protrude through the skin