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The MR approach infers causal relationships between exposures and outcomes, overcoming the limitations of observational studies, founded on three core assumptions: strong association between instrumental variables and the exposure, no association between instrumental variables and confounding factors, and instrumental variables influencing the outcome solely through their association with the exposure

To Thompsons way of thinking, all those exquisitely detailed lists of technical specifications common to virtually every other motorcycle review then in print were a waste of time

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