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Patients with cancer, for instance, may achieve higher quit rates in the absence of smoking cessation treatment due to their greater motivation to quit, they may experience greater affective distress, and the burden of imminent and taxing medical treatment may increase their level of stress

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It was hypothesised that when WT p53 expression is introduced into tumour cells, the WT p53 proteins will be activated and stabilised due to stress stimuli, such as oncogene expression, hyperproliferative signals and DNA damage