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What Is the Most Addictive Drug? Addiction Treatment Center The 5 most addictive drugs in the world The Independent The Independent Tobacco Nicotine Rutgers Addiction Research Center (RARC) Nicotine is one of the most addictive substances available. According to The National Institute on Drug Abuse NIDA, it changes the brain's reward pathways, making the body depend on it to What are the Most Addictive Drugs? Castle Craig
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