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11 "History", The Worshipful Company of Tobacco Pipe Makers and Tobacco Blenders website, www.tobaccolivery.co.uk, gathered 8/19/18

In addition to stimulating the release of norepinephrine and dopamine, nicotine also directly activates nicotinic acetylcholine receptors (nAChRs) and stimulates cellular responses including increased c-fos and c-jun expression, increased expression of heat shock proteins, induction of chromosome aberration, reduced cell proliferation, and suppression of apoptosis [33, 4044]

What this means is that people might need to take these drugs for longer than 12 weeks

Bellew B, Greenhalgh E, Winstanley M

So, without any other instructions I treated it just like I would the rest of my coffee mugs