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The diagnostic criteria include three ADHD subtypes: (1) Combined presentation of both hyperactivity and impulsivity meeting criterion A1 and A2 for at least 6 months, (2) Predominantly inattentive presentation meeting criterion A1 but not A2 for at least 6 months, and (3) Predominantly hyperactive/impulsive presentation meeting criterion A2 but not A1 for at least 6 months [ ADHD significantly impairs multiple aspects of life and has been associated with unsuccessful marriage, educational underachievement, unemployment, criminality, etc

(+)- cis -Isopulegone isomerase (iPI) then isomerizes the remaining double bond to form (+)-pulegone