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Many cafs in Ajman and Sharjah sell Esse as a softer alternative to strong Western brands

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines 31 for each of our systematic reviews, we identified studies reporting relative risk (RR) of incidence or mortality from each of the 36 selected outcomes for smokers compared with nonsmokers

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A total of 354 participants exclusively used nicotine ( n = 101), THC ( n = 247) or other substances ( n = 6) in vape devices, 233 participants used both nicotine and either THC ( n = 230) or containing other substances ( n = 3) and 10 participants used a combination of three substances, while the contents of the vape devices of the remaining 71 participants was unspecified or unknown