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13 year old yorkie who developed extreme hair & weight loss

Nicotine is a type of sympathomimetic agent that is seen in many anti-obesity drugs that also increases thermogenesis in adipose/fat tissue (they increase energy expenditure via action on peripheral tissue and through regulation of metabolism in the brain) Read more in detail @ Hey

The nic-salt ratio is distinct for different products, but you have a minimal nicotine intake

The sensitization-homeostasis model is unique in its extensive integration of clinical observations and basic science and its attribution of dependence to craving suppression and suggests that separate homeostatic mechanisms are responsible for abstinence, withdrawal, and tolerance (162)

Differences between smokers and non-smokers in regional gray matter volumes: a voxel-based morphometry study