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"Our finding that cinnamaldehyde impairs normal airway cilia motility is significant because it demonstrates that a common, food-safe flavouring agent, in the context of e-cigarette use, is capable of dysregulating a critical anti-bacterial defence system in the lungs." Reactive aldehyde chemicals in cigarette smoke are known to cause lung inflammation and increase susceptibility to bacterial and viral infection

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Moreover, expression of the cellular senescence marker p21 was not affected (Online Additional file 1)

If the patient is diagnosed in early stages (stage 1 or stage 2) and begins treatment right away, the 5-year survival rate is much higher than advanced stage patients

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