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In the national ERICA survey, adolescents aged 15 to 17 years showed higher prevalences of experimentation, current use, and frequent use than those aged 12 to 14 years

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The nicotine-induced epigenetic alterations reduced expression of mesenchymal peroxisome proliferator-activated receptor- (PPAR), a nuclear receptor that plays a critical role in lung development, homeostasis, and repair

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The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest