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10.1503/cmaj.109-4342 Lopez AD, Collishaw NE, Piha T: A descriptive model of the cigarette epidemic in developed countries

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For example, researchers concluded that emphysema in cigarette smokers reflects a low-level, chronic inflammatory process in the lower respiratory tract with an imbalance of protease and antiprotease activities leading to the degradation of connective tissue (Churg et al

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