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iQOS: In July 2020, the FDA authorized Philip Morris to market its IQOS Tobacco Heating System as a modified risk tobacco product, making the IQOS device and its accompanying HeatSticks only the second set of products to be authorized as MRTP and the first tobacco products to receive exposure modification orders

12 Future research on both cigarette use and e-cigarette use among youths is needed to continue monitoring these developments

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Mainstream Adoption of Functional Ingredients Functional ingredient integration is transitioning from niche premium products to mainstream formulations as manufacturing costs decline and consumer awareness increases

Dual use The dual use of e-cigarettes and traditional combustible cigarettes, a pattern increasingly observed worldwide, poses compounded risks for metabolic and liver health [138, 139]