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As he explains, We use smell in one of two ways orthonasal olfaction, smelling stuff from the outside when air comes through the front of the nose, and retronasal olfaction, when the air travels backwards through the nose and we essentially breath out the smell of the food we are eating. Either way, odour particles reach the olfactory epithelium, at the top of the nose, where the specialised receptor cells live. The nerves travel from the receptors upwards through a bone called the cribriform plate and into the olfactory bulb at the bottom of the brain

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Handbook of Experimental Pharmacology, 192, 29-60

The vanilla essence pairs beautifully with the light tobacco, giving you a pleasant smoke without the intensity of higher-nicotine cigars

binding to H1 receptors, for example, can trigger immune responses in the respiratory system and lead to symptoms like itching and sneezing